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Neurodegenerative Disorders Practice Questions

20 free Neurodegenerative Disorders practice questions for the Pathology, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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All Neurodegenerative Disorders questions

20 questions
  1. Q1. Which of the following pathological features is the hallmark of Alzheimer disease and is composed of abnormally phosphorylated tau protein?
  2. Q2. A 72-year-old male presents with resting tremor, bradykinesia, and rigidity. Autopsy reveals loss of pigmentation in the substantia nigra. What protein is the…
  3. Q3. In Alzheimer disease, the cleavage of Amyloid Precursor Protein (APP) by which enzyme pair leads to the generation of the amyloid-beta (Aβ) peptide?
  4. Q4. Which neurodegenerative disorder is characterized by 'knife-edge' atrophy of the frontal and temporal lobes?
  5. Q5. Huntington disease is caused by an expanded trinucleotide repeat (CAG) in the HTT gene. Which specific brain structure undergoes the most profound atrophy in t…
  6. Q6. Amyotrophic Lateral Sclerosis (ALS) involves the degeneration of which of the following?
  7. Q7. Which of the following is a characteristic histological finding in the brains of patients with Prion diseases like Creutzfeldt-Jakob Disease (CJD)?
  8. Q8. A 65-year-old patient presents with rapidly progressive dementia, visual hallucinations, and parkinsonian features. What is the most likely diagnosis?
  9. Q9. Multiple System Atrophy (MSA) is characterized by alpha-synuclein inclusions found primarily in which cell type?
  10. Q10. Which genetic mutation is the most common cause of familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)?
  11. Q11. The 'hydrocephalus ex vacuo' seen in advanced Alzheimer disease is a result of:
  12. Q12. Which protein accumulates in the spinal cord of nearly 95% of patients with Amyotrophic Lateral Sclerosis (ALS)?
  13. Q13. Progressive Supranuclear Palsy (PSP) is a tauopathy that classically presents with which clinical sign?
  14. Q14. What is the primary mechanism of neurotoxicity in Prion diseases?
  15. Q15. In Huntington disease, 'anticipation' refers to which genetic phenomenon?
  16. Q16. Which neurodegenerative condition is specifically associated with the loss of dopaminergic neurons in the locus coeruleus and substantia nigra?
  17. Q17. What is the characteristic histological inclusion found in Pick disease?
  18. Q18. A 50-year-old male presents with ataxia, autonomic instability (orthostatic hypotension), and parkinsonism. This triad is most suggestive of:
  19. Q19. Which of the following describes 'Hirano bodies' often seen in the hippocampus of Alzheimer patients?
  20. Q20. Which isoform of Apolipoprotein E (ApoE) is associated with an increased risk and earlier onset of sporadic Alzheimer disease?