Which of the following is a characteristic histological finding in the brains of patients with Prion diseases like Creutzfeldt-Jakob Disease (CJD)?
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Correct answer: Spongiform change in the gray matter neuropil
Prion diseases are characterized by 'spongiform encephalopathy,' which refers to the development of small, clear vacuoles within the neuropil and perikaryon of neurons. This is often accompanied by neuronal loss and reactive gliosis.
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