Neurodegenerative Disorders · Pathology

The 'hydrocephalus ex vacuo' seen in advanced Alzheimer disease is a result of:

  1. Excessive production of cerebrospinal fluid
  2. Obstruction of the Aqueduct of Sylvius
  3. Compensatory ventricular enlargement due to brain atrophy
  4. Failure of arachnoid granulations to resorb fluid
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Correct answer: Compensatory ventricular enlargement due to brain atrophy

In neurodegenerative conditions, the loss of brain parenchyma (atrophy) results in a secondary, compensatory enlargement of the ventricular system. This is termed hydrocephalus ex vacuo to distinguish it from high-pressure hydrocephalus.

Difficulty: Medium Question 11 of 20

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