Which isoform of Apolipoprotein E (ApoE) is associated with an increased risk and earlier onset of sporadic Alzheimer disease?
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Correct answer: ApoE ε4
The ApoE ε4 allele is a major genetic risk factor for sporadic Alzheimer disease. Inheriting one or two copies of ε4 increases the likelihood of Aβ deposition, whereas ε2 appears to have a protective effect.
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