Which of the following pathological features is the hallmark of Alzheimer disease and is composed of abnormally phosphorylated tau protein?
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Correct answer: Neurofibrillary tangles
Neurofibrillary tangles are intracellular bundles of filaments composed of hyperphosphorylated tau protein. While neuritic plaques are extracellular Aβ deposits, tangles correlate more closely with the degree of cognitive impairment.
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