Which neurodegenerative disorder is characterized by 'knife-edge' atrophy of the frontal and temporal lobes?
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Correct answer: Pick disease
Pick disease, a form of Frontotemporal Lobar Degeneration (FTLD-tau), shows severe, circumscribed atrophy of the frontal and temporal lobes. This leads to the characteristic 'knife-edge' appearance of the gyri.
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