A 50-year-old male presents with ataxia, autonomic instability (orthostatic hypotension), and parkinsonism. This triad is most suggestive of:
Show answer and explanation
Correct answer: Multiple System Atrophy (MSA)
Multiple System Atrophy encompasses syndromes previously known as Shy-Drager syndrome and Olivopontocerebellar atrophy. It is characterized by the combination of autonomic failure, parkinsonism, and ataxia.
Keep practicing
More Neurodegenerative Disorders questions
- Which of the following describes 'Hirano bodies' often seen in the hippocampus of Alzheimer patients?
- Which isoform of Apolipoprotein E (ApoE) is associated with an increased risk and earlier onset of sporadic Alzheimer disease?
- Which of the following pathological features is the hallmark of Alzheimer disease and is composed of abnormally phosphorylated tau protein?
- A 72-year-old male presents with resting tremor, bradykinesia, and rigidity. Autopsy reveals loss of pigmentation in the substantia nigra.…
- In Alzheimer disease, the cleavage of Amyloid Precursor Protein (APP) by which enzyme pair leads to the generation of the amyloid-beta (Aβ)…
- Which neurodegenerative disorder is characterized by 'knife-edge' atrophy of the frontal and temporal lobes?