Which genetic mutation is the most common cause of familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)?
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Correct answer: C9orf72 hexanucleotide repeat
The C9orf72 hexanucleotide (GGGGCC) repeat expansion is the most frequent genetic cause of both ALS and FTD. This genetic link helps explain why these two clinical syndromes often overlap in families.
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