In Alzheimer disease, the cleavage of Amyloid Precursor Protein (APP) by which enzyme pair leads to the generation of the amyloid-beta (Aβ) peptide?
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Correct answer: Beta-secretase and gamma-secretase
The amyloidogenic pathway involves the sequential cleavage of APP by β-site amyloid precursor protein cleaving enzyme (beta-secretase) followed by the gamma-secretase complex. Cleavage by alpha-secretase precludes Aβ formation.
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