Which protein accumulates in the spinal cord of nearly 95% of patients with Amyotrophic Lateral Sclerosis (ALS)?
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Correct answer: TDP-43
TDP-43 (TAR DNA-binding protein 43) is the major pathological protein in most cases of ALS and many cases of FTD. It is normally found in the nucleus but translocates to the cytoplasm and aggregates in disease states.
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