Multiple System Atrophy (MSA) is characterized by alpha-synuclein inclusions found primarily in which cell type?
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Correct answer: Oligodendrocytes
Unlike Parkinson disease where inclusions are neuronal, MSA is characterized by Glial Cytoplasmic Inclusions (GCIs). These are silver-staining inclusions of alpha-synuclein found within the cytoplasm of oligodendrocytes.
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