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Pharmacology

Adverse Drug Reactions and Interactions Practice Questions

19 free Adverse Drug Reactions and Interactions practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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All Adverse Drug Reactions and Interactions questions

19 questions
  1. Q1. Which of the following best describes a Type A adverse drug reaction (ADR)?
  2. Q2. Which is an example of a Type B (idiosyncratic) adverse drug reaction?
  3. Q3. A patient on warfarin starts a new drug that inhibits CYP2C9. What is the most likely consequence?
  4. Q4. Which mechanism underlies many serious drug–drug interactions (DDIs)?
  5. Q5. Grapefruit juice can increase plasma levels of certain medications by inhibiting which enzyme in the gut and liver?
  6. Q6. Which combination is especially dangerous due to additive risk of QT prolongation and torsades de pointes?
  7. Q7. Which factor increases the risk of adverse drug reactions in a patient?
  8. Q8. Which scenario best illustrates a pharmacodynamic drug–drug interaction?
  9. Q9. A patient develops neutropenia after a course of chloramphenicol. This ADR is best classified as which type?
  10. Q10. Which of the following increases the risk of toxicity when a drug with narrow therapeutic index is given with a strong CYP inhibitor?
  11. Q11. A patient experiences Stevens–Johnson syndrome after starting a sulfonamide antibiotic. What kind of ADR is this?
  12. Q12. Which of the following drug–drug combinations should be avoided because of high risk of serious toxicity due to interaction via CYP3A4 inhibition?
  13. Q13. When a patient’s renal function declines markedly, what happens to clearance and risk of drug toxicity for renally excreted drugs?
  14. Q14. Which of the following describes a beneficial drug–drug interaction (rather than a harmful one)?
  15. Q15. In older adults, why is the risk of adverse drug reactions higher than in younger adults?
  16. Q16. Which of the following is true about drug interactions involving food or beverages?
  17. Q17. A patient on two drugs that both depress bone marrow function is at increased risk for severe neutropenia. This is an example of which type of interaction?
  18. Q18. What is the first step in evaluating a suspected adverse drug reaction in a patient?
  19. Q19. Which statement about drug–drug interactions is correct?