Grapefruit juice can increase plasma levels of certain medications by inhibiting which enzyme in the gut and liver?
Show answer and explanation
Correct answer: CYP3A4
Grapefruit juice contains furanocoumarins that irreversibly inhibit CYP3A4 in intestinal and hepatic cells, reducing first-pass metabolism and increasing drug concentrations.
Practice all 19 Adverse Drug Reactions and Interactions questions
Keep practicing
More Adverse Drug Reactions and Interactions questions
- Which combination is especially dangerous due to additive risk of QT prolongation and torsades de pointes?
- Which factor increases the risk of adverse drug reactions in a patient?
- Which scenario best illustrates a pharmacodynamic drug–drug interaction?
- A patient develops neutropenia after a course of chloramphenicol. This ADR is best classified as which type?
- Which of the following increases the risk of toxicity when a drug with narrow therapeutic index is given with a strong CYP inhibitor?
- A patient experiences Stevens–Johnson syndrome after starting a sulfonamide antibiotic. What kind of ADR is this?