Adverse Drug Reactions and Interactions · USMLE Step 1

Which is an example of a Type B (idiosyncratic) adverse drug reaction?

  1. Hypotension from an antihypertensive
  2. Bleeding from warfarin overdose
  3. Anaphylaxis after penicillin exposure
  4. Sedation after benzodiazepines
Show answer and explanation

Correct answer: Anaphylaxis after penicillin exposure

Type B reactions are unpredictable and not dose-dependent; true drug allergies such as IgE-mediated anaphylaxis to penicillin are typical examples.

Difficulty: Medium Question 2 of 19

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