Adverse Drug Reactions and Interactions · USMLE Step 1

A patient on two drugs that both depress bone marrow function is at increased risk for severe neutropenia. This is an example of which type of interaction?

  1. Pharmacokinetic
  2. Additive pharmacodynamic
  3. Synergistic beneficial
  4. Pharmacogenetic
Show answer and explanation

Correct answer: Additive pharmacodynamic

When two drugs produce similar adverse effects (bone marrow suppression), their effects add up, increasing risk of toxicity — a classic pharmacodynamic interaction.

Difficulty: Medium Question 17 of 19

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