Adverse Drug Reactions and Interactions · USMLE Step 1

Which of the following describes a beneficial drug–drug interaction (rather than a harmful one)?

  1. Combination precipitates dangerous serotonin syndrome
  2. Two hepatotoxic drugs cause additive liver injury
  3. ACE inhibitor eases calcium channel blocker edema
  4. Macrolide raises statin levels causing myopathy
Show answer and explanation

Correct answer: ACE inhibitor eases calcium channel blocker edema

Some interactions yield therapeutic benefit—for example, ACE inhibitors may mitigate peripheral edema caused by calcium channel blockers, improving tolerability.

Difficulty: Medium Question 14 of 19

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