Adverse Drug Reactions and Interactions · USMLE Step 1

Which statement about drug–drug interactions is correct?

  1. Risk decreases as more medications are combined
  2. Interactions can only reduce a drug's effect
  3. Some interactions cause serious, preventable toxicity
  4. Only prescription medications can interact harmfully
Show answer and explanation

Correct answer: Some interactions cause serious, preventable toxicity

Some DDIs can cause serious or life-threatening adverse effects (e.g., bleeding, arrhythmia). Many are preventable by reviewing drug regimens and avoiding hazardous combinations.

Difficulty: Medium Question 19 of 19

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