Adverse Drug Reactions and Interactions · USMLE Step 1

A patient experiences Stevens–Johnson syndrome after starting a sulfonamide antibiotic. What kind of ADR is this?

  1. Dose-dependent toxicity
  2. Allergic/hypersensitivity reaction
  3. Therapeutic failure
  4. Pharmacodynamic tolerance
Show answer and explanation

Correct answer: Allergic/hypersensitivity reaction

Stevens–Johnson syndrome is a severe hypersensitivity reaction (immune-mediated), not predictable from dose or pharmacology, and thus classified as an allergic ADR.

Difficulty: Medium Question 11 of 19

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