Adverse Drug Reactions and Interactions · USMLE Step 1

Which of the following best describes a Type A adverse drug reaction (ADR)?

  1. An unpredictable immune-mediated allergic reaction
  2. Dose-related exaggeration of the drug's effect
  3. A reaction occurring only on first drug exposure
  4. An idiosyncratic host metabolic error
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Correct answer: Dose-related exaggeration of the drug's effect

Type A ADRs are dose-related and result from an exaggeration of the drug’s normal pharmacological action. They tend to be predictable and often reversible by dose reduction or stopping the drug.

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