Which condition is a classic contraindication for the use of NSAIDs due to the potential for 'triad' exacerbation (Samter's Triad)?
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Correct answer: Asthma associated with nasal polyps
In patients with Samter's Triad (asthma, nasal polyps, and aspirin sensitivity), inhibiting COX can shift arachidonic acid metabolism toward the lipoxygenase pathway. This increases the production of leukotrienes, which can trigger severe bronchospasm.
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