A patient presents with an Aspirin overdose. Which of the following is an appropriate pharmacological intervention to increase the renal excretion of the drug?
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Correct answer: Administration of Sodium Bicarbonate to alkalinize the urine
Salicylates are weak acids. Alkalinizing the urine with Sodium Bicarbonate converts salicylic acid into its ionized form (salicylate), which is 'trapped' in the renal tubules and cannot be reabsorbed, thus accelerating its excretion.
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