What is the primary mechanism by which NSAIDs cause renal impairment, especially in dehydrated patients?
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Correct answer: Vasoconstriction of the afferent arteriole
Prostaglandins normally dilate the afferent arteriole to maintain glomerular filtration. By inhibiting these prostaglandins, NSAIDs cause afferent vasoconstriction, which can lead to acute kidney injury in states where renal perfusion is already compromised.
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