NSAIDs can reduce the antihypertensive efficacy of ACE inhibitors primarily by which mechanism?
Show answer and explanation
Correct answer: Inhibiting the production of vasodilatory prostaglandins in the kidney
NSAIDs block the synthesis of vasodilatory prostaglandins (PGE2 and PGI2) that help maintain renal blood flow. This causes afferent arteriolar vasoconstriction and sodium retention, which antagonizes the blood-pressure-lowering effects of ACE inhibitors.
Keep practicing
More NSAIDs questions
- Which condition is a classic contraindication for the use of NSAIDs due to the potential for 'triad' exacerbation (Samter's Triad)?
- What is the primary mechanism by which NSAIDs cause renal impairment, especially in dehydrated patients?
- Which of the following NSAIDs is often the drug of choice for the closure of a patent ductus arteriosus (PDA) in premature infants?
- Tinnitus and hearing loss are characteristic early signs of toxicity for which class of NSAIDs?
- Misoprostol is sometimes co-administered with NSAIDs to prevent which adverse effect?
- Which property of Naproxen makes it distinct from Ibuprofen in terms of patient compliance?