Systemic Pathology by Organ · USMLE Step 1

Which gross feature is most characteristic of cirrhosis of the liver?

  1. Uniform enlargement with a smooth surface
  2. Shrunken, nodular liver with fibrous septa
  3. Multiple cystic cavities filled with bile
  4. Extensive fatty change without fibrosis
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Correct answer: Shrunken, nodular liver with fibrous septa

Cirrhosis produces diffuse fibrosis and regenerative nodules, giving the liver a shrunken, nodular surface with bridging fibrous septa — the hallmark gross finding.

Difficulty: Medium Question 8 of 19

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