Pathology

Systemic Pathology by Organ Practice Questions

19 free Systemic Pathology by Organ practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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All Systemic Pathology by Organ questions

19 questions
  1. Q1. Which lesion is most characteristic of a myocardial infarction (MI) on gross pathology, 24 hours after onset?
  2. Q2. In chronic passive congestion of the liver due to right-sided heart failure, what gross feature is most likely observed?
  3. Q3. Which glomerular disease is most likely in a patient with systemic lupus erythematosus showing “wire-loop” lesions on light microscopy?
  4. Q4. Which morphological change is most typical of long-standing pulmonary emphysema on gross lung examination?
  5. Q5. Which liver pathology is characterized by multiple, randomly distributed, blood-filled spaces within the parenchyma, sometimes associated with anabolic steroid…
  6. Q6. Which cardiac pathology is associated with asymmetric hypertrophy of the ventricular walls and histologic evidence of myofiber disarray, and may cause sudden d…
  7. Q7. In a patient with chronic hepatitis B infection, deposition of immune complexes in glomeruli may cause which renal pathology?
  8. Q8. Which gross feature is most characteristic of cirrhosis of the liver?
  9. Q9. Which vascular pathology involves a tear in the intima leading to false lumen formation within the aortic wall?
  10. Q10. Which kidney lesion is most likely to result from prolonged hypertension and lead to bilateral small kidneys with scarring?
  11. Q11. Which pathological change in the lung is most characteristic of acute lobar pneumonia on gross examination?
  12. Q12. Which of the following is the most common glomerular pathology pattern seen in patients with chronic liver disease on renal biopsy studies?
  13. Q13. Which gross feature is suggestive of pulmonary tuberculosis in lungs obtained at autopsy?
  14. Q14. Which heart pathology often leads to concentric hypertrophy of the ventricular wall due to increased afterload?
  15. Q15. Which organ is most commonly affected first in hepatorenal syndrome secondary to advanced cirrhosis?
  16. Q16. Which of the following describes a saccular true aneurysm?
  17. Q17. Which renal pathology often presents clinically with heavy proteinuria, hypoalbuminemia, edema and hyperlipidemia?
  18. Q18. Which of the following is a major mechanism by which atherosclerosis leads to ischemic heart disease?
  19. Q19. Which of the following findings in the liver is characteristic of alcoholic fatty liver disease in early stages?