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Genetics and Evolution

Population genetics Practice Questions

20 free Population genetics practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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Questions

All Population genetics questions

20 questions
  1. Q1. In a population at Hardy-Weinberg equilibrium, the frequency of a recessive disease is 1 in 10,000 individuals. What is the approximate carrier frequency?
  2. Q2. Which of the following conditions must be met for a population to maintain Hardy-Weinberg equilibrium?
  3. Q3. A rare autosomal recessive disorder affects 1 in 40,000 individuals. What is the approximate allele frequency of the mutant allele?
  4. Q4. Inbreeding in a population is most likely to increase the frequency of which of the following?
  5. Q5. A population experiences a sudden reduction in size due to natural disaster. Which population genetics concept best describes the resulting change?
  6. Q6. A small group leaves a large population and establishes a new isolated community. After generations, a previously rare allele becomes more common. Which effect…
  7. Q7. If p = 0.7 in a Hardy-Weinberg population, what is the expected heterozygote frequency?
  8. Q8. Which of the following violates the Hardy-Weinberg assumption of random mating?
  9. Q9. Migration of individuals between populations results in which genetic effect?
  10. Q10. A heterozygote advantage helps maintain alleles in a population by:
  11. Q11. If a population has allele frequencies p = 0.4 and q = 0.6, what is the expected frequency of homozygous recessive individuals?
  12. Q12. Which factor is most likely to increase genetic variation within a population?
  13. Q13. In a recessive disease, the carrier frequency is found to be approximately 1/25. What is the approximate disease prevalence?
  14. Q14. Directional selection acts on a population by:
  15. Q15. A population in which one allele becomes 100% prevalent has undergone:
  16. Q16. Which situation exemplifies genetic drift?
  17. Q17. Which event increases homozygosity within a population?
  18. Q18. In Hardy-Weinberg equilibrium, which term represents the frequency of heterozygotes?
  19. Q19. Which factor most strongly disrupts Hardy-Weinberg equilibrium by introducing new alleles?
  20. Q20. A new population is formed by 10 individuals who carry an unusually high frequency of a recessive allele. After several generations, the allele remains common.…