Population genetics · USMLE Step 1

Which of the following violates the Hardy-Weinberg assumption of random mating?

  1. Large population size
  2. Selection against heterozygotes
  3. Consanguinity
  4. Low mutation rates
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Correct answer: Consanguinity

Consanguinity (inbreeding) is a form of non-random mating that increases homozygosity. Random mating is essential for Hardy-Weinberg equilibrium. Selection and mutation violate different assumptions.

Difficulty: Medium Question 8 of 20

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