Population genetics · USMLE Step 1

If p = 0.7 in a Hardy-Weinberg population, what is the expected heterozygote frequency?

  1. 0.21
  2. 0.42
  3. 0.14
  4. 0.49
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Correct answer: 0.42

Heterozygote frequency is 2pq = 2(0.7)(0.3) = 0.42. This assumes population stability and random mating. The other values correspond to homozygous frequencies or incorrect calculations.

Difficulty: Medium Question 7 of 20

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