Population genetics · USMLE Step 1

A population experiences a sudden reduction in size due to natural disaster. Which population genetics concept best describes the resulting change?

  1. Founder effect
  2. Genetic drift
  3. Gene flow
  4. Heterozygote advantage
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Correct answer: Genetic drift

Genetic drift is a random change in allele frequencies, most prominent in small populations. A sudden reduction magnifies drift. The founder effect is a specific subtype involving migration.

Difficulty: Medium Question 5 of 20

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