Which scenario would decrease the effective therapeutic index of a drug in a patient?
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Correct answer: Renal impairment causing drug accumulation
Renal impairment can lead to drug accumulation and higher plasma concentrations. This increases the risk of toxicity without changing the effective dose. As a result, the practical therapeutic index narrows.
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More Therapeutic Index questions
- In clinical practice, the therapeutic index is most relevant for drugs that:
- Which parameter indicates the median dose producing toxicity in 50% of subjects?
- A drug’s therapeutic index does NOT account for:
- Which change would widen the therapeutic index of a drug?
- In which phase of drug development is therapeutic index primarily determined?
- The therapeutic index (TI) of a drug is best defined as: