The certain safety factor is calculated as:
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Correct answer: LD1/ED99
The certain safety factor (or margin of safety) is calculated as LD1 divided by ED99. It represents a more conservative measure of safety than LD50/ED50. This accounts for variability in response among individuals.
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More Therapeutic Index questions
- Which scenario would decrease the effective therapeutic index of a drug in a patient?
- In clinical practice, the therapeutic index is most relevant for drugs that:
- Which parameter indicates the median dose producing toxicity in 50% of subjects?
- A drug’s therapeutic index does NOT account for:
- Which change would widen the therapeutic index of a drug?
- In which phase of drug development is therapeutic index primarily determined?