Which change would widen the therapeutic index of a drug?
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Correct answer: Increase in LD50 with constant ED50
Therapeutic index equals LD50 divided by ED50. Increasing LD50 while keeping ED50 constant increases the ratio, thereby widening the therapeutic index. This indicates a greater margin of safety.
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More Therapeutic Index questions
- In which phase of drug development is therapeutic index primarily determined?
- The therapeutic index (TI) of a drug is best defined as:
- A drug with a high therapeutic index is generally considered to be:
- Which of the following drugs is known to have a narrow therapeutic index?
- If the ED50 of a drug is 10 mg and the LD50 is 100 mg, the therapeutic index is:
- The therapeutic window of a drug refers to: