In which phase of drug development is therapeutic index primarily determined?
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Correct answer: Preclinical animal studies
Therapeutic index is primarily determined in preclinical animal studies using LD50 and ED50 values. These experiments establish the safety margin before human trials begin. Clinical trials further assess safety but do not rely on LD50 measurements.
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More Therapeutic Index questions
- The therapeutic index (TI) of a drug is best defined as:
- A drug with a high therapeutic index is generally considered to be:
- Which of the following drugs is known to have a narrow therapeutic index?
- If the ED50 of a drug is 10 mg and the LD50 is 100 mg, the therapeutic index is:
- The therapeutic window of a drug refers to:
- Which factor does NOT directly influence the therapeutic index of a drug?