Which parameter indicates the median dose producing toxicity in 50% of subjects?
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Correct answer: TD50
TD50 is the median toxic dose that produces a specific toxic effect in 50% of subjects. It is used in calculating therapeutic index when lethality is not the endpoint. This helps quantify drug safety.
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More Therapeutic Index questions
- A drug’s therapeutic index does NOT account for:
- Which change would widen the therapeutic index of a drug?
- In which phase of drug development is therapeutic index primarily determined?
- The therapeutic index (TI) of a drug is best defined as:
- A drug with a high therapeutic index is generally considered to be:
- Which of the following drugs is known to have a narrow therapeutic index?