Therapeutic Index · Pharmacology

A drug with a high therapeutic index is generally considered to be:

  1. Less potent but more effective
  2. More likely to cause toxicity at therapeutic doses
  3. Safer with a wider margin of safety
  4. Highly protein-bound in plasma
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Correct answer: Safer with a wider margin of safety

A high therapeutic index indicates a wide separation between effective and toxic doses. This means the drug can be administered with a lower risk of serious toxicity. Therefore, such drugs are considered relatively safer.

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