Which route of administration bypasses the first-pass metabolism completely?
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Correct answer: Intravenous injection
Intravenous administration delivers the drug directly into systemic circulation. Because it bypasses the gastrointestinal tract and liver initially, the drug avoids first-pass metabolism.
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More First-Pass Effect questions
- Which drug property is most likely to be affected by a strong first-pass effect?
- Which blood vessel carries absorbed drugs from the gastrointestinal tract to the liver for first-pass metabolism?
- Which alternative route is often used to avoid the first-pass effect for drugs like nitroglycerin?
- Which factor increases the likelihood of a significant first-pass effect?
- Which pharmacokinetic process occurs before the first-pass effect?
- Which drug administration route partially avoids the first-pass effect?