Which factor increases the likelihood of a significant first-pass effect?
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Correct answer: High hepatic enzyme activity
High hepatic enzyme activity increases the metabolism of drugs during their first pass through the liver. This results in greater loss of active drug before it reaches systemic circulation.
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More First-Pass Effect questions
- Which pharmacokinetic process occurs before the first-pass effect?
- Which drug administration route partially avoids the first-pass effect?
- Which enzyme system in the liver is mainly responsible for first-pass drug metabolism?
- Which pharmacokinetic concept describes the proportion of drug reaching systemic circulation after administration?
- Which drug characteristic may increase the impact of the first-pass effect?
- Which statement best explains why some drugs are ineffective when given orally?