Which pharmacokinetic process occurs before the first-pass effect?
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Correct answer: Absorption
After oral administration, a drug must first be absorbed from the gastrointestinal tract. Once absorbed, it enters the portal circulation and is subject to first-pass metabolism.
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More First-Pass Effect questions
- Which drug administration route partially avoids the first-pass effect?
- Which enzyme system in the liver is mainly responsible for first-pass drug metabolism?
- Which pharmacokinetic concept describes the proportion of drug reaching systemic circulation after administration?
- Which drug characteristic may increase the impact of the first-pass effect?
- Which statement best explains why some drugs are ineffective when given orally?
- Which dosage adjustment may be necessary for drugs with a strong first-pass effect?