Which route of drug administration is most affected by the first-pass effect?
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Correct answer: Oral administration
Orally administered drugs pass through the gastrointestinal tract and then the portal circulation to the liver. During this passage, they may be metabolized before reaching systemic circulation.
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More First-Pass Effect questions
- Which route of administration bypasses the first-pass metabolism completely?
- Which drug property is most likely to be affected by a strong first-pass effect?
- Which blood vessel carries absorbed drugs from the gastrointestinal tract to the liver for first-pass metabolism?
- Which alternative route is often used to avoid the first-pass effect for drugs like nitroglycerin?
- Which factor increases the likelihood of a significant first-pass effect?
- Which pharmacokinetic process occurs before the first-pass effect?