Which alternative route is often used to avoid the first-pass effect for drugs like nitroglycerin?
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Correct answer: Sublingual administration
Sublingual administration allows the drug to be absorbed directly into systemic circulation through oral mucosa. This route bypasses the liver's first-pass metabolism.
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More First-Pass Effect questions
- Which factor increases the likelihood of a significant first-pass effect?
- Which pharmacokinetic process occurs before the first-pass effect?
- Which drug administration route partially avoids the first-pass effect?
- Which enzyme system in the liver is mainly responsible for first-pass drug metabolism?
- Which pharmacokinetic concept describes the proportion of drug reaching systemic circulation after administration?
- Which drug characteristic may increase the impact of the first-pass effect?