Which drug property is most likely to be affected by a strong first-pass effect?
Show answer and explanation
Correct answer: Bioavailability
The first-pass effect reduces the fraction of drug that reaches systemic circulation unchanged. Therefore, it significantly reduces the bioavailability of many orally administered drugs.
Keep practicing
More First-Pass Effect questions
- Which blood vessel carries absorbed drugs from the gastrointestinal tract to the liver for first-pass metabolism?
- Which alternative route is often used to avoid the first-pass effect for drugs like nitroglycerin?
- Which factor increases the likelihood of a significant first-pass effect?
- Which pharmacokinetic process occurs before the first-pass effect?
- Which drug administration route partially avoids the first-pass effect?
- Which enzyme system in the liver is mainly responsible for first-pass drug metabolism?