Which drug administration route partially avoids the first-pass effect?
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Correct answer: Rectal administration
Rectal administration can partially bypass the liver because some of the rectal venous drainage enters systemic circulation directly. However, part of the drug may still undergo hepatic metabolism.
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More First-Pass Effect questions
- Which enzyme system in the liver is mainly responsible for first-pass drug metabolism?
- Which pharmacokinetic concept describes the proportion of drug reaching systemic circulation after administration?
- Which drug characteristic may increase the impact of the first-pass effect?
- Which statement best explains why some drugs are ineffective when given orally?
- Which dosage adjustment may be necessary for drugs with a strong first-pass effect?
- Which tissue besides the liver may contribute to first-pass metabolism?