Which enzyme system in the liver is mainly responsible for first-pass drug metabolism?
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Correct answer: Cytochrome P450 enzymes
Cytochrome P450 enzymes are responsible for metabolizing many drugs during the first-pass process. They convert drugs into more water-soluble metabolites.
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More First-Pass Effect questions
- Which pharmacokinetic concept describes the proportion of drug reaching systemic circulation after administration?
- Which drug characteristic may increase the impact of the first-pass effect?
- Which statement best explains why some drugs are ineffective when given orally?
- Which dosage adjustment may be necessary for drugs with a strong first-pass effect?
- Which tissue besides the liver may contribute to first-pass metabolism?
- Which type of drug is most affected by the first-pass effect?