Which statement best explains why some drugs are ineffective when given orally?
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Correct answer: They undergo extensive first-pass metabolism
Some drugs are extensively metabolized during their first passage through the liver. As a result, only a small fraction reaches systemic circulation, making oral administration ineffective.
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More First-Pass Effect questions
- Which dosage adjustment may be necessary for drugs with a strong first-pass effect?
- Which tissue besides the liver may contribute to first-pass metabolism?
- Which type of drug is most affected by the first-pass effect?
- Which pharmacological strategy can reduce the impact of the first-pass effect?
- Which physiological factor influences the extent of the first-pass effect?
- Which statement best summarizes the clinical significance of the first-pass effect?