Which drug characteristic may increase the impact of the first-pass effect?
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Correct answer: Extensive hepatic metabolism
Drugs that are extensively metabolized in the liver are more susceptible to the first-pass effect. This can greatly reduce their systemic availability after oral administration.
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More First-Pass Effect questions
- Which statement best explains why some drugs are ineffective when given orally?
- Which dosage adjustment may be necessary for drugs with a strong first-pass effect?
- Which tissue besides the liver may contribute to first-pass metabolism?
- Which type of drug is most affected by the first-pass effect?
- Which pharmacological strategy can reduce the impact of the first-pass effect?
- Which physiological factor influences the extent of the first-pass effect?