A polymorphism in the VKORC1 gene primarily affects which pharmacokinetic or pharmacodynamic process of Warfarin?
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Correct answer: Sensitivity of the target enzyme in the vitamin K cycle
VKORC1 encodes the enzyme Vitamin K epoxide reductase, the target of warfarin. Genetic variations in this promoter region determine the baseline level of the enzyme, significantly influencing the dose required for anticoagulation.
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