TPMT genotyping is used to guide the dosing of which class of drugs?
Show answer and explanation
Correct answer: Thiopurines (e.g., azathioprine)
TPMT is responsible for metabolizing thiopurine drugs. Patients with low or absent TPMT activity will accumulate toxic levels of thioguanine nucleotides, leading to severe bone marrow suppression if standard doses are used.
Keep practicing
More Pharmacogenomics questions
- Which CYP450 polymorphism is most relevant for the activation of the antiplatelet drug Clopidogrel?
- The 'Ultra-rapid Metabolizer' phenotype of CYP2D6 is associated with which clinical outcome in a patient taking Codeine?
- Polymorphisms in the UGT1A1 gene, specifically the UGT1A1*28 allele, are associated with toxicity from which chemotherapeutic agent?
- Which genotype-based drug interaction occurs when a 'Poor Metabolizer' of CYP2C19 is given Omeprazole?
- What is the primary clinical consequence of G6PD deficiency when a patient is exposed to oxidant drugs like Primaquine?
- The SLCO1B1 gene encodes a transporter protein that facilitates the hepatic uptake of which drug class?