The 'Ultra-rapid Metabolizer' phenotype of CYP2D6 is associated with which clinical outcome in a patient taking Codeine?
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Correct answer: Morphine toxicity and overdose
Ultra-rapid metabolizers have multiple copies of the CYP2D6 gene, leading to excessive conversion of codeine to morphine. This can result in dangerously high morphine levels, causing respiratory depression even at standard doses.
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