Testing for the HLA-B*57:01 allele is mandatory before prescribing which antiretroviral drug to prevent hypersensitivity reactions?
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Correct answer: Abacavir
Abacavir hypersensitivity is a multi-organ clinical syndrome strongly linked to the HLA-B*57:01 allele. Screening has effectively reduced the incidence of this potentially fatal reaction to near zero.
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