Polymorphisms in the UGT1A1 gene, specifically the UGT1A1*28 allele, are associated with toxicity from which chemotherapeutic agent?
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Correct answer: Irinotecan
UGT1A1 is responsible for the glucuronidation (inactivation) of SN-38, the active metabolite of irinotecan. Patients with the *28 allele have reduced enzyme expression, leading to increased SN-38 levels and severe neutropenia/diarrhea.
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